Understanding Dupuytren's disease using systems biology: a move away from reductionism.
- Resource Type
- Article
- Authors
- Rehman, Samrina; Day, Philip J. R.; Bayat, Ardeshir; Westerhoff, Hans V.
- Source
- Frontiers in Physiology; Aug2012, Vol. 3, p1-4, 4p
- Subject
- DUPUYTREN'S contracture
METACARPOPHALANGEAL joint
MULTIPLE endocrine neoplasia
MYOFIBROBLASTS
CONTRACTURE (Pathology)
- Language
- ISSN
- 1664042X
The article offers information on Dupuytren's disease (DD) which can cause permanent flexion contracture of the metacarpophalangeal (MCP) and proximal interphalangeal joints (PIPJ) leading to loss of functioning. It states that DD behaves as a benign neoplastic disorder. It further focuses on nodules which are highly vascularized, soft-tissue masses containing myofibroblasts.