Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA.
- Resource Type
- Article
- Authors
- Jang, Sang-Min; Kang, Eun-Jin; Kim, Jung-Woong; Kim, Chul-Hong; An, Joo-Hee; Choi, Kyung-Hee
- Source
- Biochemical & Biophysical Research Communications. Aug2013, Vol. 438 Issue 2, p445-451. 7p.
- Subject
- *TRANSCRIPTION factors
*SOX transcription factors
*APOPTOSIS
*HISTONE deacetylase inhibitors
*TRICHOSTATIN A
*GENE expression
*PROMOTERS (Genetics)
- Language
- ISSN
- 0006-291X
Highlights: [•] TSA induces PUMA transcription in a p53-independent manner. [•] Transcription factor Sox4 directly regulates PUMA promoter activity. [•] TSA-mediated induction of PUMA expression is regulated by Sox4-dependent p300 recruitment in PUMA promoter. [ABSTRACT FROM AUTHOR]