Sample preparation for combined chemical analysis and in vitro bioassay application in water quality assessment.
- Resource Type
- Article
- Authors
- Kolkman, Annemieke; Schriks, Merijn; Brand, Walter; Bäuerlein, Patrick S.; van der Kooi, Margaretha M.E.; van Doorn, René H.; Emke, Erik; Reus, Astrid A.; van der Linden, Sander C.; de Voogt, Pim; Heringa, Minne B.
- Source
- Environmental Toxicology & Pharmacology. Nov2013, Vol. 36 Issue 3, p1291-1303. 13p.
- Subject
- *BIOLOGICAL assay
*WATER quality
*SOLID phase extraction
*MASS spectrometry
*GENETIC toxicology
*MATERIA medica
*BIODIVERSITY
- Language
- ISSN
- 1382-6689
Highlights: [•] We report a sample preparation method suitable in chemical analysis and in vitro bioassays. [•] Chemicals were extracted from surface water samples using solid phase extraction. [•] The extracts were chemically analyzed using broad screening on a Orbitrap mass spectrometer. [•] The extracts were analyzed for genotoxic activity and for specific endocrine receptor activation. [•] Measured responses in bioassays were compared with the predicted responses based on recovery. [ABSTRACT FROM AUTHOR]