For nurses, the challenges posed by demanding work environments and schedules often lead to fatigue, and this can be exacerbated during crises like the COVID-19 pandemic. In this article, the authors discuss causes and challenges of nurse fatigue and consider several evidence-based strategies and solutions for individual nurses and organizations. Barriers to implementation, including a negative workplace culture and inadequate staffing, are also described, and several resources are presented. This article discusses causes and challenges of nurse fatigue, evidence-based strategies and solutions for individual nurses and organizations, and changes needed to transform nursing culture and workplaces into more supportive environments for nurses. [ABSTRACT FROM AUTHOR]