(e) Immunohistochemistry showing CD68-positive cells in and around the follicle, (f) CD80-positive cells in the follicle, (g) CD163-positive cells around the follicle, (h) CD1a-positive cells in the follicle, and (i) CD11c-positive cells around the follicle gl The underlying pathomechanisms of EPF are still unclear.1 Immunohistochemical staining revealed CD68-positive cells in and around the follicle (Fig. Dense infiltration of M2 macrophages has been reported in the perifollicular areas of the lesional skin.4 M1 macrophage activity inhibits cell proliferation and causes tissue damage, while M2 macrophage activity promotes cell proliferation and tissue repair.5 It is possible that M1 macrophages are associated with the disease pathogenesis by initiating and sustaining inflammation in the follicles. We originally intended to stain M1 macrophages with CD80 antibodies, but neither the staining pattern nor morphology of CD80-positive cells completely matched the CD68-positive macrophages. [Extracted from the article]