Is XPR1 mediating phosphate efflux?
- Resource Type
- Article
- Authors
- Hernando, Nati
- Source
- Pflügers Archiv: European Journal of Physiology. May2024, Vol. 476 Issue 5, p717-719. 3p.
- Subject
- *PROXIMAL kidney tubules
*BRUSH border membrane
*PHOSPHATES
*CELL receptors
*NEURAL stem cells
*FANCONI syndrome
*CELL culture
- Language
- ISSN
- 0031-6768
The article discusses the role of XPR1 in mediating phosphate efflux in cells. While the transporters involved in phosphate uptake are well-known, the identity of the efflux pathway(s) is not fully understood. XPR1 has been proposed as a candidate for this role, and previous studies have shown that XPR1 is involved in phosphate efflux and regulates phosphate homeostasis. However, recent research suggests that XPR1 may not stimulate phosphate efflux and raises questions about its precise activity and expression in different cell types. Further research is needed to better understand the role of XPR1 in phosphate transport. [Extracted from the article]