The potential role of bisphosphonates in prostate cancer.
- Resource Type
- Article
- Authors
- Oades, G M; Coxon, J; Colston, K W
- Source
- Prostate Cancer & Prostatic Diseases. 2002, Vol. 5 Issue 4, p264. 9p.
- Subject
- *PROSTATE cancer
*DIPHOSPHONATES
*BONE metastasis
- Language
- ISSN
- 1365-7852
Skeletal morbidity secondary to metastases and osteoporosis is common in patients with advanced prostate cancer. Despite the typically sclerotic nature of prostate cancer metastases, osteoclast mediated osteolysis may play a significant role. This review addresses the newly recognised antitumour effects of bisphosphonates in addition to their role in inhibiting osteoclast mediated bone resorption. Both preclinical and clinical evidence of a role for bisphosphonates in the treatment and prevention of bone metastases secondary to prostate cancer is assessed.Prostate Cancer and Prostatic Diseases (2002) 5, 264-272. doi:10.1038/sj.pcan.4500607 [ABSTRACT FROM AUTHOR]