LOX-1 Regulation in Anti-atherosclerosis of Active Compounds of Herbal Medicine: Current Knowledge and the New Insight
- Resource Type
- Review Paper
- Authors
- Yao, Si-jie; Lan, Tao-hua; Zhang, Xin-yu; Zeng, Qiao-huang; Xu, Wen-jing; Li, Xiao-qing; Huang, Gui-bao; Liu, Tong; Lyu, Wei-hui; Jiang, Wei
- Source
- Chinese Journal of Integrative Medicine. 29(2):179-185
- Subject
- atherosclerosis
herbal medicine
lectin-like oxidized low-density lipoprotein receptor-1
targeted therapy
- Language
- English
- ISSN
- 1672-0415
1993-0402
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) have recently been identified to be closely related to the occurrence and development of atherosclerosis (AS). A growing body of evidence has suggested Chinese medicine takes unique advantages in preventing and treating AS. In this review, the related research progress of AS and LOX-1 has been summarized. And the anti-AS effects of 10 active components of herbal medicine through LOX-1 regulation have been further reviewed. As a potential biomarker and target for intervention in AS, LOX-1 targeted therapy might provide a promising and novel approach to atherosclerotic prevention and treatment.