Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
- Resource Type
- other
- Authors
- Wu, Wanting; Liang, Yuan; Wu, Guangchao; Su, Yinghang; Zhang, Hongying; Zhang, Zhenyan; Deng, Changsheng; Wang, Qi; Huang, Bo; Tan, Bo; Zhou, Chongjun; Song, Jianping
- Source
- Revista da Sociedade Brasileira de Medicina Tropical. January 2019 52
- Subject
- ECG
QT
Artemisinin-piperaquine
Malaria
Cambodia
- Language
- English
- ISSN
- 0037-8682
INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria. METHODS: This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study. RESULTS: Some cases of QT prolongation were observed. However, no TdP was found. CONCLUSIONS: AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.