Objective: To determine the association between access to adequate personal protective equipment (PPE) and mental health outcomes among a sample of U.S. nurses. Methods: An online questionnaire was administered in May 2020 to Michigan nurses via three statewide nursing organizations (n = 695 respondents). Multivariable logistic regression analysis was used to identify factors associated with mental health symptoms. Results: Nurses lacking access to adequate PPE (24.9%. n = 163) were more likely to report symptoms of depression (OR 1.96, 95% CI 1.31, 2.94. P= 0.001), anxiety (OR 1.64, 95% CI 1.12, 2.40: P =0.01) and post-traumatic stress disorder (OR 1.83. 95% CI 1.22. 2.74; P= 0.003). Conclusions: Healthcare organizations should be aware of the magnitude of mental health problems among nurses and vigilant in providing them with adequate PPE as the pandemic continues. [ABSTRACT FROM AUTHOR]