Cognitive Radio and Femtoce11 are recent technology breakthroughs that aim to achieve throughput improvement by means of spectrum management and interference mitigation, respectively. However, these technologies are limited by cognitive radio's susceptibility to interference and Femtoce11's dependence on bandwidth availability. We propose our integrated architecture and optimization framework based on power control, coverage assignment and compensation schemes. Based on our numerical results, the optimization framework is both stable and converging; also, our simulation studies show that the proposed architecture and optimization framework improves the aggregate throughput as client population rise hence confirming the successful and beneficial integration of these technologies.