Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: an integrated analysis of metabolic and transcriptomic data
- Resource Type
- Academic Journal
- Authors
- Stevens, A; Bonshek, C; Whatmore, A; Butcher, I; Hanson, D; De Leonibus, C; Shaikh, G; Brown, M; OʼShea, E; Victor, S; Powell, P; Settle, P; Padmakumar, B; Tan, A; Odeka, E; Cooper, C; Birch, J; Shenoy, A; Westwood, M; Patel, L; Dunn, B W; Clayton, P
- Source
- The Pharmacogenomics Journal. Aug 01, 2014 14(4):376-384
- Subject
- Language
- English
- ISSN
- 1470-269X
Small for gestational age (SGA) children exhibiting catch-up (CU) growth have a greater risk of cardiometabolic diseases in later life compared with non-catch-up (NCU) SGA children. The aim of this study was to establish differences in metabolism and gene expression profiles between CU and NCU at age 4-9 years. CU children (n=22) had greater height, weight and body mass index standard deviation scores along with insulin-like growth factor-I (IGF-I) and fasting glucose levels but lower adiponectin values than NCU children (n=11; all P<0.05). Metabolic profiling demonstrated a fourfold decrease of urine myo-inositol in CU compared with NCU (P<0.05). There were 1558 genes differentially expressed in peripheral blood mononuclear cells between the groups (P<0.05). Integrated analysis of data identified myo-inositol related to gene clusters associated with an increase in insulin, growth factor and IGF-I signalling in CU children (P<0.05). Metabolic and transcriptomic profiles in CU SGA children showed changes that may relate to cardiometabolic risk.