Real-time label-free detection of DNA synthesis by FBAR-based mass sensing
- Resource Type
- Conference
- Authors
- Lin, Anderson; Sahin, Furkan E.; Chen, Shih-Jui; Pham, Phuong; Kim, Eun Sok
- Source
- 2010 IEEE International Ultrasonics Symposium Ultrasonics Symposium (IUS), 2010 IEEE. :1286-1289 Oct, 2010
- Subject
- Components, Circuits, Devices and Systems
Bioengineering
Communication, Networking and Broadcast Technologies
Computing and Processing
Signal Processing and Analysis
Photonics and Electrooptics
Fields, Waves and Electromagnetics
Engineered Materials, Dielectrics and Plasmas
DNA
Film bulk acoustic resonators
Polymers
Frequency measurement
Resonant frequency
Electrodes
Gold
- Language
- ISSN
- 1051-0117
1948-5727
1948-5719
This paper reports a real-time detection of DNA polymerase reaction through mass sensing with film bulk acoustic resonator (FBAR) coated with self-assembled DNA sequences. This label-free, real-time detection of DNA synthesis can potentially lead to detection of single nucleotide addition for DNA sequencing application, which can be developed into a low-cost, third-generation DNA sequencing system capable of reading thousands of nucleotides in a single run.