In order to overcome the limitations of traditional methods for detecting melanoma in dermoscopy images, a novel method based on deep learning for melanoma detection in dermoscopy images is proposed in this paper. This detection method combines deep learning method, realizes the combination of deep learning method and traditional detection method of melanoma in dermoscopy image, and fully utilizes the advantages of convolution neural network, residual network and transfer learning. The results show that the detection method has strong feasibility and can effectively improve the accuracy of melanoma detection in dermoscopy images.