Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps
- Resource Type
- article
- Authors
- Xiaojuan Li; Mengting Hu; Zhangjun Wang; Mei Liu; Ying Chen
- Source
- Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-10 (2024)
- Subject
- Prevalence
Colorectal polyps
Neoplastic polyps
Colorectal carcinoma in situ
Tumor markers
Medicine
- Language
- English
- ISSN
- 1479-5876
Abstract Background Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps. Methods Inpatients admitted from January 2018 to May 2023 were screened through the hospital information system. Polyps were classified according to pathological morphology. The prevalence of polyps was described by frequency and 95% confidence interval. Univariate and multivariate logistic regression analyses were used to explore the risk factors for CCS and neoplastic polyps. Results In total, 2329 individuals with 3550 polyps were recruited. Among all patients, 76.99% had neoplastic polyps and 44.31% had advanced adenomas. Tubular adenoma had the highest prevalence at 60.15%, and the prevalence of CCS was 3.86%. Patients with a colorectal polyp diameter ≥ 1.0 cm or number ≥ 3 were 8.07 times or 1.98 times more likely to develop CCS than were those with a diameter 1.0 cm) or multifocal polyps. The levels of the tumor markers CA724 and CA211 show some potential usefulness for predicting CCS and may be exploited for early identification of high-risk populations.