目的 提高对气管壁增厚类疾病及不典型气管支气管淀粉样变性(TBA)的认识,减少临床误诊及漏诊率.方法 回顾1例不典型TBA病例,并结合国内外文献对该病例特殊性进行临床分析.结果 该病例影像学提示气管壁弥漫增厚;支气管镜下未见明显异常;活检无出血;病理苏木精-伊红染色无明确提示,后刚果红染色阳性确诊为TBA,因症状轻未予特殊治疗,定期随访示气道壁增厚有所改善.结论 TBA为呼吸系统罕见疾病,其可存在不典型表现,更易出现误诊,需临床医师提高警惕.
Objective To enhance the understanding of diseases with thickening of tracheobronchial wall and atypical tracheobronchial amyloidosis(TBA),to decrease its misdiagnosis and missed diagnosis rate.Methods A case of atypical tracheobronchial amyloidosis was shared with its specificity analysed according to the review of literature at home or abroad.Results The case of atypical TBA showed diffuse thickening of tracheobronchial wall,with no obvious abnormality under bronchoscopy,no bleeding during biopsy,no clear manifestations in HE staining,but confirmed by positive Congo red staining.No specific treatment was given to the patient due to mild symptoms.Imaging manifestations of the patient improved during short-time follow-up.Conclusions Tracheobronchial amyloidosis is a relatively rare disease of respiratory system.Tracheobronchial amyloidosis may have atypical manifestations and could be misdiagnosed,which required the vigilance of clinicians.