Introduction: Transition from paediatric to adult care is a critical time for patients with CF. Evaluation of the impact of this on clinical outcomes can facilitate improved quality of care. Aim: To identify whether the process of transition and transfer has significant impact on the clinical status of patients and highlight areas requiring quality improvement. Methods: Data was collected from 44 adolescent patients with cystic fibrosis at 1 year increments for two years before and after transition comparing spirometry, height, weight, BMI,home intravenous antibiotic use, microbiological colonisation, outpatient attendance and inpatient admissions before and after transition. The data included all patients who transitioned from Princess Margaret Hospital for Children, Western Australia to Sir Charles Gardiner Hospital, Western Australia 2008-2012. Results: On average, FEV and FVC z-scores decreased from pre to post transition by 0.44 (±0.60) and 0.40 (±0.58). FEV and FVC % predicted also decreased from pre to post transition by 5.22% (±7.45%) and 4.79% (±6.62%). Days on Home Intravenous Antibiotic Therapy and outpatient visits attended increased from pre to post transition by an average of 1.96 (±8.5) and 2.92 (±3.4) per year respectively. The number of days as an inpatient increased by an average of 1.71 (±6.33) from pre to post transition. Conclusion: Spirometry declined in the two years post transition.Transition did not have a negative impact on weight .The mean number of days spent as an inpatient was higher pre transition.Patients had more days on home Intravenous Antibiotic Therapy and more outpatient visits post-transition.