Design of the ANal Cancer/HSIL Outcomes Research study (ANCHOR study): A randomized study to prevent anal cancer among persons living with HIV
- Resource Type
- Authors
- Lee, Jeannette Y; Lensing, Shelly Y; Berry-Lawhorn, J Michael; Jay, Naomi; Darragh, Teresa M; Goldstone, Stephen E; Wilkin, Timothy J; Stier, Elizabeth A; Einstein, Mark; Pugliese, Julia C; Palefsky, Joel M; ANCHOR Investigators
- Source
- Subject
- Outcome Assessment
Prevention
Papillomavirus Infections
Clinical Trials and Supportive Activities
HIV Infections
Anus Neoplasms
Medical and Health Sciences
Clinical trial design
Health Care
Infectious Diseases
Risk Factors
Clinical Research
Surveys and Questionnaires
Persons living with HIV
Humans
HIV/AIDS
ANCHOR Investigators
Anal cancer prevention
Public Health
Digestive Diseases
General Clinical Medicine
Cancer
- Language
It is well established that persons living with HIV (PLWH) have highly elevated rates of anal HSIL and anal cancer compared with those who are not living with HIV. The 5-year risk of anal cancer following anal HSIL has been reported to be as high as 14.1% among PLWH compared with 3.2% among those who are not living with HIV. To address these concerns, the AIDS Malignancy Consortium completed a large-scale, randomized trial to compare strategies for the prevention of anal cancer among PLWH with anal HSIL. The objective of the study was to determine whether treating anal HSIL was effective in reducing the incidence of anal cancer in PLWH compared with active monitoring. This paper describes the design of the ANal Cancer/HSIL Outcomes Research Study (ANCHOR) with respect to estimating the anal cancer event rate in this high risk population.