Early colon screening of adult patients with cystic fibrosis reveals high incidence of adenomatous colon polyps
- Resource Type
- Authors
- Joanne Billings; Aleh Bobr; Alexander Khoruts; Sandra McAllister; Tyler Herzog; Jordan M. Dunitz
- Source
- Journal of clinical gastroenterology. 48(9)
- Subject
- Oncology
Adult
Male
medicine.medical_specialty
Cystic Fibrosis
Colorectal cancer
Minnesota
Population
Colonoscopy
Gastroenterology
Cystic fibrosis
Sex Factors
Internal medicine
medicine
Humans
Gastrointestinal cancer
education
Early Detection of Cancer
education.field_of_study
Adenomatous colon polyps
medicine.diagnostic_test
business.industry
Incidence (epidemiology)
Incidence
Middle Aged
medicine.disease
Colon polyps
Adenomatous Polyposis Coli
Female
business
- Language
- ISSN
- 1539-2031
Cystic fibrosis (CF) is associated with increased incidence of gastrointestinal cancer. Increasing overall life expectancy of CF patients predicts emergence of colon cancer as a significant clinical problem in the adult CF population. The primary aim of this study was to estimate the incidence of adenomatous colon polyps in patients with CF during systematic screening by colonoscopy.This is a single-center series of 45 CF patients aged 40 years and above (mean age, 47 y) undergoing colonoscopic screening. A fraction of these patients (9/45) had history of organ transplantation. Results from transplant and nontransplant patients were analyzed separately.Adult CF patients have a high incidence of adenomatous polyps identified by colonoscopy. In addition, positive examinations are characterized by multiple polyps and common features of advanced pathology. The incidence of adenomatous colon polyps is greater in male patients, although the 1 patient in this cohort found to have colorectal cancer was female.CF has features of a hereditary colon cancer syndrome. Increasing life expectancy of CF patients suggests that earlier colon screening in this population may be warranted. Optimal criteria for initiation of screening and frequency of surveillance should be subject of further studies.