DNA translocation through solid-state nanopore
- Resource Type
- Authors
- Ziyin Zhang; Deqiang Wang; Yue Zhao; Daming Zhou; Yunsheng Deng; Qimeng Huang; Xiaojing Zhao
- Source
- Journal of Micro-Bio Robotics. 14:35-40
- Subject
- 0301 basic medicine
Nucleic acid quantitation
Chemistry
Mechanical Engineering
Solid-state
Sequence (biology)
02 engineering and technology
021001 nanoscience & nanotechnology
DNA sequencing
Nucleobase
03 medical and health sciences
Nanopore
030104 developmental biology
Membrane
Biophysics
Molecule
General Materials Science
Electrical and Electronic Engineering
0210 nano-technology
- Language
- ISSN
- 2194-6426
2194-6418
Solid-state nanopore is a promising alternative for current nucleic acid analysis in DNA sequencing. In this work, we employed current-stimulus dielectric breakdown to fabricate a 2 nm nanopore on SiNx membrane. The effect of this 2 nm SiNx nanopore was then examined by comparing the translocation behaviors of four types of ssDNA through this nanopore. Current signal collected from the nanopore can distinguish the four types of ssDNA with 30 nucleobases and 100 nucleobases, providinginformation about the sequence and structure of the ssDNA molecule.