In the South Asian region, Pakistan has the largest share of the young population which can transform the future of the country. Unfortunately, this hidden potential is untouched due to the poor infrastructure of higher educational institutes. This study explores the youth's entrepreneurial skills for sustainable start-ups by discussing different youth entrepreneurial skills based on economic, social, individual, and political factors. The data is collected through the five-point scale questionnaire and targeted the final-year students of various universities in the Lahore district. The key objective of this study is to determine the various factors of youth entrepreneurship for the start-up new business. The multiple regression econometrics approaches concluded that all factors of youth entrepreneurship such as political, economic, individual, and social factors significantly and positively impact the start-up of new business.