MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma OncogeneTransforming Growth Factor-1 Pathway
- Resource Type
- Article
- Authors
- Pan, Zhenwei; Sun, Xuelin; Shan, Hongli; Wang, Ning; Wang, Jinghao; Ren, Jinshuai; Feng, Shuya; Xie, Liangjun; Lu, Chunying; Yuan, Ye; Zhang, Yang; Wang, Ying; Lu, Yanjie; Yang, Baofeng
- Source
- Circulation (Ovid); August 2012, Vol. 126 Issue: 7 p840-850, 11p
- Subject
- Language
- ISSN
- 00097322; 15244539
Cardiac interstitial fibrosis is a major cause of the deteriorated performance of the heart in patients with chronic myocardial infarction. MicroRNAs (miRs) have recently been proven to be a novel class of regulators of cardiovascular diseases, including those associated with cardiac fibrosis. This study aimed to explore the role of miR-101 in cardiac fibrosis and the underlying mechanisms.