Turn Structures in CGRP C-Terminal Analogues Promote Stable Arrangements of Key Residue Side Chains.
- Resource Type
- Article
- Authors
- Carpenter, Katharine A.; Schmidt, Ralf; von Mentzer, Bengt; Haglund, Ulla; Roberts, Edward; Walpole, Chris
- Source
- Biochemistry. 7/17/2001, Vol. 40 Issue 28, p8317. 9p. 11 Diagrams, 3 Charts, 4 Graphs.
- Subject
- *CALCITONIN gene-related peptide
*LIGAND binding (Biochemistry)
*CELL receptors
- Language
- ISSN
- 0006-2960
Explores the conformational and structural features of calcitonin gene-related peptide (CGRP)(27-37)-NH[sub 2] analogues that are important for high affinity (h)CGRP[sub 1] receptor binding. Biological effects mediated by CGRP; Conformational similarities between A[sup 34] and P[sup 34] analogue series; Important residues for biological activity.