Introduction: organ weights at postmortem examination of deceased Nigerians are compared with that of Caucasians to determine pathologies and cause of death. Indigenous data is needed because of the differences in race and lifestyle. Materials end Method: this is an eleven-year retrospective study. Postmortem findings and summarized clinical notes of deceased Nigerians archived in the Department of Pathology, University College Hospital Ibadan, from January 1, 2008 to December 31, 2018 were reviewed. Inclusion criteria were age ≥18≤70 years, traumatic or sudden unexpected death with no pathology in the heart, and no history or postmortem features of hypertension. Data on Age, gender, cause of death, body length, heart weights, heart valves circumference and ventricular wall thickness were retrieved. Descriptive statistics, student t-test and regression analysis was done using SPSS 20. Confidence limit was set at p < 0.05. Results: eighty-five cases fulfilled all the criteria comprising of 64 males and 21 females with mean age of 39.1±13.8 years and 37.21±11.0 years respectively. The mean heart weights for males and females differed significantly with a mean of 310.8±40.3g (220-405g) and 261.32±34.0g (200-325g) respectively (p<0.000). The mean body length for males and females also differed significantly with mean of 1.7±0.1m and 1.62±0.1m respectively (p<0.002). However, there was non-significant difference in age between males and females (p>0.05). Multiple regression analysis suggests that only gender is a likely predictor of heart weight (p<0.001). The mean circumference of the tricuspid, mitral, pulmonary and aortic valves were 11.2cm, 9.3cm, 7.2cm, and 6.4cm respectively whilst the mean left and right ventricular wall thickness were 1.3cm and 0.3cm respectively. Conclusion: heart weights and valvular circumference of adult Nigerians Heart weights of apparently healthy adult Nigerians differ by gender and show ranges beyond values from other populations. [ABSTRACT FROM AUTHOR]