Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models.
- Resource Type
- journal article
- Authors
- Lee, Dokwan; Hong, Ki-Taek; Lim, Tae Seong; Lee, Eugene; Lee, Ye Hyun; Park, Ji Soon; Kim, Woo; Oh, Joo Han; Choi, Jung-Ah; Song, Yongnam
- Source
- BMC Musculoskeletal Disorders. 7/2/2020, Vol. 21 Issue 1, p1-12. 12p. 5 Diagrams, 2 Charts, 2 Graphs.
- Subject
- *ARTICULAR cartilage
*MENISCECTOMY
*TENDONS
*SURGICAL excision
*RELAXATION for health
*BONES
- Language
- ISSN
- 1471-2474
Background: The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilateral supraspinatus tendon resections, and 2) to find the relationship between regional variations in articular cartilage loading patterns and T2* relaxation time distributions.Methods: Rigid markers were implanted in the scapula and humerus of tested dogs. The movement of the shoulder bones were measured by a motion tracking system during normal gaits. In vivo cartilage contact strain was measured by aligning 3D shoulder models with the motion tracking data. Articular cartilage T2* relaxation times were measured by quantitative MRI scans. Articular cartilage contact strain and T2* relaxation time were compared in the shoulders before and 3 months after the supraspinatus tendon resections.Results: Excellent accuracy and reproducibility were found in our in vivo contact strain measurements with less than 1% errors. Changes in articular cartilage contact strain exhibited similar patterns with the changes in the T2* relaxation time after resection surgeries. Regional changes in the articular cartilage T2* relaxation time exhibited positive correlations with regional contact strain variations 3 months after the supraspinatus resection surgeries.Conclusion: This is the first study to measure in vivo articular cartilage contact strains with high accuracy and reproducibility. Positive correlations between contact strain and T2* relaxation time suggest that the articular cartilage extracellular matrix may responds to mechanical changes in local areas. [ABSTRACT FROM AUTHOR]