Resistance Profile of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor...
- Resource Type
- Article
- Authors
- Harrigan, P. Richard; Stone, Chris; Griffin, Phillip; Najera, Isabel; Bloor, Stuart; Kemp, Sharon; Tisdale, Margaret; Larder, Brendan
- Source
- Journal of Infectious Diseases. 3/1/2000, Vol. 181 Issue 3, p912. 9p.
- Subject
- *REVERSE transcriptase
*HIV infections
*THERAPEUTICS
*DRUG resistance in microorganisms
*CHEMICAL inhibitors
- Language
- ISSN
- 0022-1899
Studies the resistance profile of the HIV-1 reverse transcriptase inhibitor abacavir after monotherapy and combination therapy. Construction of recombinant HIV-1 strains from clinical isolates; Viral passage and growth competition; Mapping of genetic determinants of abacavir resistance.