Background: Female genital mutilation (FGM) has become recognized worldwide as an extreme form of violation of the human rights of girls and women. Strategies have been employed to curb the practice.Objective: To conduct a systematic review of randomized and nonrandomized studies of the effects of providing educational interventions on the body image and care-seeking behavior of girls and women living with FGM with the view to ending the practice.Search Strategy: CENTRAL, MEDLINE, and other databases were searched up to August 10, 2015 without any language restrictions.Selection Criteria: Studies that provided education to women and/or girls living with any type of FGM or residing in countries where FGM is predominantly practiced were included.Data Collection and Analysis: Two authors independently screened and collected data. We summarized dichotomous outcomes using odds ratios and evidence was assessed using the GRADE system (Grading of Recommendations Assessment, Development, and Evaluation).Results: Educational interventions resulted in fewer women recommending FGM for their daughters and also reduced the incidence of FGM cases among daughters of women who received the educational interventions.Conclusion: These findings need to be validated with large randomized trials.Prospero Registration: 42015024637. [ABSTRACT FROM AUTHOR]